Gambogic Acid ( B-Guttiferrin; Beta-Guttiferrin; Beta-Guttilactone )

Catalog No. M17464 CAS No. 2752-65-0

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Product Name

Gambogic Acid
Note

Research use only, not for human use.
Brief Description

Gambogic Acid ( EC50=0.78-1.64 uM) activates caspases. Gambogic Acid competitively suppresses Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1.
Description

Gambogic acid is a xanthonoid that is derived from the brownish or orange resin from Garcinia hanburyi. This natural chemical has shown promising antitumor activity in clinical trials. Gambogic acid inhibits cell proliferation, angiogenesis and metastasis. Gambogic acid is currently in clinical trials in China.
Synonyms

B-Guttiferrin; Beta-Guttiferrin; Beta-Guttilactone
Pathway

Cell Cycle/DNA Damage
Target

Integrin
Recptor

Bfl-1; Mcl-1; Bcl-2; Bcl-B; Bcl-w
Research Area

Cancer
Indication

——

CAS Number

2752-65-0
Formula Weight

628.75
Molecular Formula

C38H44O8
Purity

97%
Solubility

DMSO : ≥ 100 mg/mL 159.05 mM; H2O : < 0.1 mg/mL
SMILES

[C@]123C4(OC(C2C[C@@H](C=C1C(=O)c1c(O3)c(c2c(c1O)C=CC(O2)(CCC=C(C)C)C)CC=C(C)C)C4=O)(C)C)C/C=C(/C(=O)O)\C
Chemical Name

(Z)-4-((1S,3aR,5S,11R,14aS)-8-hydroxy-2,2,11-trimethyl-13-(3-methylbut-2-en-1-yl)-11-(4-methylpent-3-en-1-yl)-4,7-dioxo-2,3a,4,5,7,11-hexahydro-1H-1,5-methanofuro[3,2-g]pyrano[3,2-b]xanthen-3a-yl)-2-methylbut-2-enoic acid

1. Zhai D, et al. Mol Y Ther, 2008, 7(6), 1639-1646.

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